Hepatitis B Virus Infection in Indonesia 15 Years after Adoption of a Universal Infant Vaccination Program: Possible Impacts of Low Birth Dose Coverage and a Vaccine-Escape Mutant

Purwono, Priyo Budi (2021) Hepatitis B Virus Infection in Indonesia 15 Years after Adoption of a Universal Infant Vaccination Program: Possible Impacts of Low Birth Dose Coverage and a Vaccine-Escape Mutant. The American Journal of Tropical Medicine and Hygiene, 95 (3). pp. 674-679. ISSN 0002-9637

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Abstract

A universal hepatitis B vaccination program for infants was adopted in Indonesia in 1997. Before its implementation, the prevalence of hepatitis B surface antigen (HBsAg)–positive individuals in the general population was approximately 5–10%. The study aimed to investigate the hepatitis B virus (HBV) serological status and molecular profile among children, 15 years after adoption of a universal infant vaccination program in Indonesia. According to the Local Health Office data in five areas, the percentages of children receiving three doses of hepatitis B vaccine are high (73.9–94.1%), whereas the birth dose coverage is less than 50%. Among 967 children in those areas, the seropositive rate of HBsAg in preschool- and school-aged children ranged from 2.1% to 4.2% and 0% to 5.9%, respectively. Of the 61 HBV DNA–positive samples, the predominant genotype/subtype was B/adw2. Subtype adw3 was identified in genotype C for the first time in this population. Six samples (11.5%) had an amino acid substitution within the a determinant of the S gene region, and one sample had T140I that was suggested as a vaccine-escape mutant type. The low birth dose coverage and the presence of a vaccine-escape mutant might contribute to the endemicity of HBV infection among children in Indonesia

Item Type:	Article
Uncontrolled Keywords:	Hepatitis, anak usia 15 tahun
Subjects:	R Medicine > RB Pathology R Medicine > RT Nursing
Divisions:	Jurusan Kesehatan Lingkungan Jurusan Kesehatan Lingkungan Jurusan Kesehatan Lingkungan
Depositing User:	Erika Resi
Date Deposited:	22 Jun 2021 08:22
Last Modified:	22 Jun 2021 08:22
URI:	http://repository.poltekeskupang.ac.id/id/eprint/2988

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