Acute Toxicity And Antipyretic Test Of Faloak (Sterculia quadrifida, R.Br) Leaves As Traditional Medicine

Fernandez, Stefany S. A. and Mbunga, Dominus and Amaral, Acacio Cardoso and Lau, lidya and Feoh, Putriasa (2022) Acute Toxicity And Antipyretic Test Of Faloak (Sterculia quadrifida, R.Br) Leaves As Traditional Medicine. In: 2nd ICPHS 2022, 19 dan 20 Oktober 2022, Gorontalo.

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Abstract

Objective: The aim of the study was to provide information about the efficacy and safety of Faloak leaves in the development of new traditional medicines. Methods: Identification and characterization of the extract was carried out at the beginning. In the acute toxicity test, a single oral dose of 2000 mg/KgBw of extract was given to five mice at 24 h intervals. Animals were observed individually for any clinical signs of toxicity or mortality for 14 days. DPT-Hb was used as a fever inducer in the antipyretic test of infusion and ethanol extract of faloak leaves. Results: For acute treatment, the extract did not reveal any signs of toxicity or mortality in any animal, during the 14 days observation period. The LD50 of extract was estimated to be greater than 2000 mg/KgBw. A dose of 2000 mg/KgBw in mice for 14 days showed significant side effects on the liver and spleen which were marked by organ weights that were significantly different from the control group. Paracetamol as positive control, IDF 100% and EEDF 400 mg/KgBw showed a significant difference (p<0.05) with the negative control group. Conclusion: The results showed that faloak leaf has potential as an antipyretic, but liver function must be monitored, even though the LD50 value is above 2000 mg/KgBw.

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